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A year after the death of his friend and partner Sherlock Holmes, Dr John Watson resumes his medical career at a clinic dedicated to the treatment of rare diseases However, he soon finds that his old life is not done with him yet

Rejected after a marriage proposal, Alex finds himself alone on a journey from Los Angeles to Melbourne, Australia, on what was supposed to be a happy vacation with his new fiancee Stuck in a mild state of shock, Alex crosses paths